Job Description

MiRXES is a Singapore-headquartered molecular diagnostic company with R&D, manufacturing, and clinical lab operations in Singapore, USA, Japan, and China. We specialize in microRNA technologies and th MiRXES is a Singapore-headquartered molecular diagnostic company with R&D, manufacturing, and clinical lab operations in Singapore, USA, Japan, and China. We specialize in microRNA technologies and the development, manufacturing, and provision of diagnostic test kits and clinical services. Our mission is to enable early disease detection and provide insights for better patient care by harnessing the power of microRNA to augment traditional testing. Our vision is to be the world's leading developer and provider of accurate, actionable, and affordable microRNA-powered diagnostic tests. MiRXES Lab is the R&D arm of MiRXES, comprising Data Science, Clinical Development, Product Development and Assay Development. The Assay Development group uses insights from our own database of clinical markers as well as published literature to develop tools to sensitively and specifically measure analytes of interest. We develop new technologies to improve the performance of existing approaches. Job Summary: The Assay Development Scientist will spearhead at least one project related directly to a pipeline diagnostic product. The scientist will design, optimize and perform preliminary validation work resulting in a prototype proposal for further product development. The scientist will also investigate, optimize and implement relevant technologies from either published or commercial sources to improve the performance of current tools. In the course of work, the scientist may create new intellectual property in the form of technology disclosures, patents, or publications. The Assay Development Scientist will report to Director, Assay Development. The scientist may also have direct reports in the form of one or more Research Officers. Roles and Responsibilities: Lead development and optimization of clinical diagnostic tests based on molecular technology e.g. RT-PCR, isothermal amplification, NGS (60-80% wet lab time) Apply specific aspects of molecular technology to detection of miRNA, DNA methylation, mutations as well as pathogens of interest e.g EBV, HPV Continuously explore new technologies to meet/exceed current clinical requirements on diagnostics tests and improve existing methods Design and manage projects, problem-solve using technical knowledge, design control and awareness of basic regulatory issues. Design and execute experiments independently as well as coordinate a research team that may comprise scientists and/or research officers Troubleshoot, analyse, summarize and communicate data accurately and succinctly Keep a detailed record of experiments according to R&D guidelines Actively provide scientific input in both multifunctional and R&D team meetings Work closely with other colleagues to provide scientific inputs related to company products or their area of work Train junior team members in experimental Desired Skills and Competencies: PhD / Master's degree in molecular biology, biochemistry or similar discipline. Bachelor's degree with 4 years of relevant work experience and strong evidence of at least 1 year of independent research/development work may be substituted At least 2 years of relevant experience in molecular biology research and/or development. At least 1 year of experience in assay design and development in oncology or infectious disease-related areas is preferred. Familiarity with regulatory/quality assurance processes is an advantage. A strong understanding of primer design, buffer/enzyme optimization for RT-qPCR and/or other relevant technology. Fluency in other molecular detection methodologies, especially NGS and DNA methylation analysis, will be an added advantage. A hands-on' approach and welcome challenges. Ability to work independently. Flexibility to lead or be part of a team. Ability to communicate clearly and effectively, especially on scientific concepts and about experimental design and results.