Job Description

Key Responsibilities



Design and execute in vivo mouse experiments, including but not limited to animal handling, antigen administration and tissue harvesting.

Isolate primary cells from mouse or human tissues, cell culture of primary mammalian cells.

Engineer stable cell lines by designing, generating, and using lentivirus or other transduction modalities.

Perform comprehensive cell analyses using:

Molecular biology techniques, e.g., DNA/RNA extraction, PCR, qPCR, molecular cloning, and gene expression analysis.

Bulk and single cell RNA sequencing

Flow cytometry

Serological assays e.g., ELISA

Analyze and interpret data.

Maintain thorough laboratory records.

Prepare technical reports, presentations, and manuscripts that may eventually contribute to regulatory applications (e.g. IND) and peer reviewed publications.

Collaborate across multidisciplinary teams, including scientific and translational partners.



Job Requirements



Ph.D. in Immunology, Cell/Molecular Biology, Structural Biology, Biochemistry, or a related field.

Demonstrated hands-on experience with mouse models, including antigen dosing and tissue dissection, is required.

Proficiency in primary cell isolation and culture, including from mouse or human tissues.

Strong technical skills in biochemistry.

Solid foundation in molecular biology and genetics, including construct design and cloning.

Familiarity with single-cell transcriptomics or related high-dimensional platforms, animal models and/or immunological techniques is advantageous.

Excellent verbal and written communication skills, including the ability to present scientific findings clearly and effectively.

Proven ability to complete and communicate scientific projects, as evidenced by at least one peer-reviewed (co-)first authored publication.

Highly organized, self-motivated, and capable of working independently and in cross-functional teams.

Able to maintain detailed laboratory records to be used for potential regulatory filings.

Comfortable with tight timelines and milestone-gated projects.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Type of Employment :

Full-Time

Work Location :

Biopolis