Job Description

Project Overview

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The Singapore MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group is seeking a Senior Research Engineer/Research Engineer for a project: "The pathobiology of tRNA modifications in cardiac development and diseased cell states". This is a collaborative project with the NUS Yong Loo Lin School of Medicine to map the tRNA epitranscriptome and proteome in cardiac cell development and disease states, and to characterize potential next-generation early detection biomarkers for heart failure to complement existing clinical biomarkers. The successful candidate will utilize and acquire expertise in cardio-biology and multi-omics techniques, and contribute to impactful scientific and translational research.

Responsibilities

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This role will suit an individual passionate about cardio-biology and proteomics studies to understand molecular mechanisms of protein translation and to develop potential biomarkers in heart development and disease. The candidate will be able to:


Design and perform proteomics experiments (eg, TMT, DIA, DDA)

Develop and optimize sample preparation workflows

Perform operation, maintenance and data acquisition on high-resolution mass spectrometers

Analyze data using advanced pipelines and support biological interpretation.

characterize and develop potential biomarkers for early detection of heart failure

Ensure compliance with lab safety, QC standards, and data integrity policies

Maintains highly organized sample and data tracking and reporting workflow

Requirements

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BS or MS in biochemistry, analytical chemistry, chemical engineering or related field

Experience in mass spectrometry-based proteomics and data analysis

Experience in sample preparation for proteomics analysis

Experience in operating Thermo nano liquid chromatography and Orbitrap mass spectrometer

Familiar with proteomics software as well as other bioinformatics tools and databases

Excellent attention to detail, organizational skills, and ability to maintain accurate and detailed records.

Strong communication and the ability to collaborate effectively with cross-functional teams.

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.