Job Description

Talo Systems is an early-stage therapeutics focused company based in Singapore. Led by a team of experienced drug development and computer scientists, we are a multi-disciplinary team of software developers, artificial intelligence engineers, bioinformaticians, chemists, and more. Together, our team is working to change the way that therapeutics are developed \xe2\x80\x94 at all phases of pre-clinical research and development.

A successful candidate will have a good understanding of computational chemistry principles and drug discovery, and possess the necessary problem solving and communication skills to collaborate in a multi-discipline team setting. The position requires an individual with a strong work ethic who is highly motivated and excited to work in a collaborative environment.

Responsibilities:

• Use of in silico method to support design of small molecule drugs targeting disease relevant pathways
• Use of in silico methods to support identification and discovery of disease relevant targets and pathways
• Responsible for route selection, design, and multi-step synthesis
• Keep up to date knowledge of relevant literature and technology methodologies
• Must possess good scientific problem-solving ability

• Degree or Ph.D. in relevant subjects such as Computational Chemistry (preferred) or Organic Chemistry
• Demonstrated record of productivity in Medicinal or synthetic chemistry and Molecular Dynamics Simulation research as evidenced by publications and/or patents
• Medicinal Chemistry knowledge and experience \xe2\x80\x93 3 years minimum
• Knowledge and prior experience in structure-based and ligand-based drug design, HTVS and quantum-mechanical calculations
• Proficient in related softwares such as: Gaussian, AutoDock, Maestro Schrodinger, Assisted Model Building with Energy Refinement, and Visual Molecular Dynamics
• Proficient in programming languages such as: R, Python, Bash and Fortran
• Excellent scientific problem-solving skills with the ability to perform research independently
• Strong interpersonal and communication skills (both written and verbal)
• Ability to work collaboratively in a team

Talo Labs