Job Description

"Any sufficiently advanced technology is indistinguishable from magic. -Arthur C. Clarke"At Genetic Design and Magic Corporation (GDMC), we believe in bringing the magic of novel genetic medicines to patients by innovating in manufacturing technologies that are critical to the delivery of that vision. This exponential improvement in manufacturing will allow for de-bottleneck the clinical testing and approval of new genetic medicines such as gene therapies to make blind people see, or the next mRNA vaccines.GDMC is a venture-backed, fast-paced and Singapore-HQ'ed start-up and we want you to join us on this mission, to accelerate our growth by sourcing, screening and supplying key talent for all of GDMC!As one of our Process Development Scientists (Downstream), you will be in charge of developing and optimizing multiple downstream purification processes make the production of next-generation medicines more scalable and thus, more economical and affordable. You will also work closely with the our partner-clients, the upstream side of our PD department as well as with our manufacturing experts to ensure our processes are designed for manufacturability. Join us in building a world-changing process development team housed in our state of the art multi-million biomanufacturing facility. If you'd like to play a part in bringing the next life-saving innovations to market, we want you!GDMC is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. We are committed to achieving a diverse workforce through application of equal opportunity and non-discrimination policy in all aspects of employment including recruitment, hiring, promotions, terminations, salary administration and benefits.Responsibilities Perform downstream validation for newly developed manufacturing processing to ensure scalability and robustness. Interact with the client partner on a daily or weekly basis to analyse their existing process for transferability and scalability. Prepare and follow standard operating procedures, batch records, and other process documentation. Manage the internal process development technicians and interns in proper laboratory techniques and scientific experimental design as necessary Design and troubleshoot experiments for testing various unit operations in process development in accordance with clients need and company's overall strategic goals Participate in the tech transfer process with manufacturing team to ensure smooth and seamless scale-up transition.Minimum Requirements PhD in bioprocessing, pharmaceutical science, chemical engineering or equivalent. 1-5 years of work experience within bioprocessing, bio-manufacturing, or equivalent. Demonstrable proficiency designing and troubleshooting downstream process experiments. Demonstrated proficiency in a wide variety of analytical techniques with tangential flow filtration, chromatography (SEC, IEX, UF-DF), compendial methods (e.g. pH, Osmolality, Karl Fisher titration, etc.), gels, bioassays and immunoassays. Innovative and analytical thinker with outstanding interpersonal, communication, and leadership skills.Desired Qualifications Strong understanding of cell line development, upstream and downstream, and fill/finish integrating within an integrated manufacturing context Experience working with viral gene therapeutics (AAV, Lentivirus, Retrovirus) or nucleic acid therapies (mRNA, siRNA). Strong EDA fundamentals and working with statistical analysis software.
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