Job Description

We are seeking a motivated and competent post-doctoral fellow to work on funded research project aimed at deciphering the roles of MOAP-1 in cellular senescence and ageing-associated disorders in liver. Long term goal of the project is to gain novel insights towards developing viable approaches for mitigating development and progression of liver NAFLD-associated liver diseases including NASH and HCC.Successful candidate will have the opportunity to work with a multidisciplinary team as well as collaborators in Singapore and overseas.To facilitate a better understanding of the work being pursued in the laboratory, prospective applicants can refer to the following papers published by the lab:1. K.O. Tan et al., MAP-1 is a mitochondrial effector of Bax, (Track II), Proc. Natl. Acad. Sci. USA, 102: 14623-14688, 2005. (https://doi.org/10.1073/pnas.0503524102)
2. N.Y. Fu et al., Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria, (Track II), Proc. Natl. Acad. Sci. USA, 104: 10051-10056, 2007. (https://doi.org/10.1073/pnas.0700007104)
3. N.Y. Fu et al., Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism, Molecular Cell, 33: 15-29, 2009. (https://doi.org/10.1016/j.molcel.2008.11.025)
4. S.K. Sukumaran et al., A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 37: 768-783, 2010. (https://doi.org/10.1016/j.molcel.2010.02.015
5. C.T. Tan et al., MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria, Cell Reports, 16:174-85, 2016. (https://doi.org/10.1016/j.celrep.2016.05.068)
6. C.T. Tan et al., MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling, EMBO Reports, 22: e50854, 2021. (Featured as the cover story in Jan, 2021 issue: https://doi.org/10.15252/embr.202050854)
7. H.C. Chang et al., The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore, Autophagy, 2021. (https://doi.org/10.1080/15548627.2021.1896157)
8. C.T. Tan et al., p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities. FEBS J, 290: 892-912, 2023. (https://doi.org/10.1111/febs.16317)Responsibilities include:

• Planning and execution of experiments
• Collect and analyze research data
• Guiding and working with junior staffs, including graduate/undergraduate students
• Participation in preparation of manuscripts and other reports
• Uphold research integrity and ensure safety compliance
• Perform other related duties incidental to the work described therein.

Interested candidates please submit a detailed curriculum vitae, contact information of 4 referees and indicating your earliest availability.Please note that only shortlisted candidates will be notified.QualificationsQualifications / Discipline:
Ph.D. degree in Molecular Biology, Biochemistry, Cancer biology or other related fields is preferred.Skills:
- Good communication skills and a team player.
- Effective oral and written management communication skills.
- Ability to work in a fast-paced environment.
- Other desirable attributes: self-motivated, organized, meticulous, efficient, and flexible.Experience:
Applicants with research experiences in mouse models and/or molecular and cell biology techniques (e.g., primary cell preparations, CRISPR-Cas9 gene editing, confocal microscopy, FACS, histology, IHC, IF or protein-protein interaction) are preferred.More InformationLocation: Kent Ridge CampusOrganization: ScienceDepartment : Pharmacy and Pharmaceutical SciencesJob requisition ID : 24904

National University of Singapore