Job Description

Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on organoid research?

Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.

We now seek a Research Scientist/ Fellow to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537). The role will provide expertise in the establishment, genetic manipulation and maintenance of human and murine organoid cultures as well as design/ perform and analyse work within the project parameters.

Duties And Responsibilities

Research:

• develop hypotheses and conceptualise, design and execute experiments to address the hypothesis
• to establish, engineer (e.g. by CRISPR) and maintain 3D organoid cultures from a variety of tissue systems
• to carry out molecular and cell biology experiments (i.e. cloning, FACS, western blotting, RNA, sequencing, microscopy) and perform analysis and determinations
• to organise, preserve and present the results of the experiments in a logical manner
• to properly and systematically record all experiments that have been assigned and their results
• to assist in supervising, training and guiding attachment/undergraduate students where required

Qualifications

ESSENTIAL qualifications include: * a PhD with 1-3 years\' relevant post-doctoral experience,

• strong track record of research achievement evidenced by high-quality publications in a relevant field,
• high-level experience in hands-on use of a wide range of relevant research methods with a focus on organoid work,
• skills in working independently and creatively to solve experimental problems and
• effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports.

Preference will be given to candidates with: * Familiarity with the development of phenotypic assays for genetic or chemical screening, involving the use of flow cytometry, high-throughput high-content microscopy, and/or advanced fluorescence microscopy;

• Previous experience with genetically engineered murine models, or
• Knowledge of IRB, HBRA & IACUC regulations

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.

Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.

Times Higher Education