Job Description

Our Research Scientists are our Inventors. We discover and target steps in disease mechanisms or pathways, intending to identify effective agents in treating or preventing human disease. We collaborate to discover the next medical bre Our Research Scientists are our Inventors. We discover and target steps in disease mechanisms or pathways, intending to identify effective agents in treating or preventing human disease. We collaborate to discover the next medical breakthrough using innovative thinking, state-of-the-art facilities, and robust scientific methodology. Our Research Laboratories in Singapore seek a Senior Scientist with a strong background in cancer cell biology and extensive hands-on experience in advanced imaging-based cell assay development. The candidate will play a critical role in applying efforts to identify, evaluate and implement creative solutions to advance capabilities in target-based and phenotypic profiling of cell model systems in high-content 3D imaging and analysis. Join Our Research Laboratory in Singapore for an exciting journey to set up the Imaging Mass spectrometry capabilities within the Target & Pathway Biology group (Singapore). You will provide scientific leadership and strong expertise in imaging mass spectrometry and focus on developing workflows to support drug discovery pipelines by facilitating decision making based on spatial distribution of proteins, lipids, metabolites, and candidate drugs. Utilizing state of the art Mass spectrometry platforms within the site, you will be responsible for the application and development of the mass spectrometry technology to understand novel biological regulatory mechanisms, identify disease and pharmacodynamic biomarkers. You will work closely with other scientists and will coordinate and integrate collaborative projects with other local and global scientists as well as with academic and clinical investigators in Singapore. You should have excellent background and track record in Imaging Mass spectrometry and having diverse interests in systems biology. What should you have: Subject matter expert in mass spectrometry especially in Imaging Mass spectrometry platforms. Lead and Implement generation, integration, and interpretation of spatial multi-omics and LC-MS datasets (Metabolomics, Lipidomics and Proteomics) as part of a multi-modal approach to drive pipeline decisions. Perform analytical validation, and develop QC practices. Continuously optimize and improve the Imaging mass spectrometry platform to support scientific/business processes, seeks opportunities and provides recommendations to enhance capability and support to improve safety, quality, speed, efficiency, and costs. Contribute, define, and implement the Target and Pathway Biology department research strategy aligned with drug discovery approaches and organizational objectives and serve as a technical specialist in cross-discipline project teams. Identify, evaluate, and recommend innovative analytical technologies and emerging MS platforms or capital investment opportunities to maximize the group efficiency and meet scientific. Work collaboratively on projects with matrix teams within the department and other cross functional teams. Proactively pre-empt and respond to emerging project needs to align with business and departmental strategy. Identify, evaluate, and recommend innovative analytical technologies and emerging MS platforms or capital investment opportunities to maximize the group efficiency and meet scientific objectives. Supervise, train and mentor junior scientists to develop new bioanalytical and imaging assays employing complicated or technically demanding methods in MS-based approaches. Operate autonomously to draft research project proposals, reports, publications, and other scientific communications related to research activities. Effectively develop and present a compelling case for research proposals, working collaboratively to gain support for such proposals. Ensure reliable documentation of experiments and results in electronic notebooks and other documents in compliance with company policies and project needs. Identify the need for and ensure the implementation of risk assessments and SOPs as appropriate. Sustain visibility, both inside and outside of disease or functional area by collaborating and presenting complex ideas and data. Proactively plan and execute own career development strategy that advances technical and functional knowledge that contribute to overall direction of department/discipline. Demonstrate consistent leadership behaviors. Ensure all activities comply with company codes of practice and local rules. Promote a culture of compliance among reports and colleagues. Involves in various site-related activities. Qualification: PhD in Analytical Sciences, Chemistry, Biomedical/Biological/Life Sciences related discipline with more than five years of relevant mass spectrometry experience, or BSc/MSc in related discipline with significant research experience in mass spectrometry and independent scientific achievement. Proven track record with strong background and experience in Imaging Mass spectrometry-based proteomics, metabolomics or lipidomics platforms. Experience: Hands-on experience and expertise in MS-based metabolomics, lipidomics or proteomics workflows with demonstrated track record. Expertise in operation, troubleshooting and maintenance of high-resolution mass spectrometers, triple quadrupoles, and Imaging MS instrumentation. Experience in data mining, integration, and interpretation of multi-modal imaging MS datasets is preferred. Highly collaborative yet independent scientist that excels in a matrix environment. Strong team player that has a positive, proactive, can-do attitude. Excellent problem solving and troubleshooting skills. Professional competencies Professional competencies in alignment with company's R&D Competency model for level with particular emphasis on leadership, problem solving, working across boundaries, and productive communication. Functional competencies Demonstrates leadership skills in alignment with company's leadership behaviors appropriate for level. We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we 'follow the science' and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world. What we look for In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace. Current Employees apply Current Contingent Workers apply Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.